||Exposure of Humans to Ambient Levels of Ozone for 6.6 Hours Causes Cellular and Biochemical Changes in the Lung.
Devlin, R. B. ;
McDonnell, W. F. ;
Mann, R. ;
Becker, S. ;
House., D. E. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. School of Medicine. ;ABB Environmental Services, Inc., Chapel Hill, NC.
Air pollution effects(Humans) ;
Pulmonary fibrosis ;
Bronchoalveolar lavage fluid ;
Interleukin 6 ;
Lactate dehydrogenase ;
Alpha 1-antitrypsin ;
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||An acute (2h) exposure of humans to 0.4 ppm ozone initiates biochemical changes in the lung resulting in the production of components which mediate inflammation and acute lung damage as well as components which have the potential to lead to long term effects such as fibrosis. However, many people are exposed to lower levels of ozone than this, but for periods of several hours. Therefore, it is important to determine if a prolonged exposure to low levels of ozone is also capable of causing cellular and biochemical changes in the lung. Non-smoking males were randomly exposed to filtered air and either 0.10 ppm ozone or 0.08 ppm ozone for 6.6 h with moderate exercise (40 1/min). Bronchalveolar lavage (BAL) was performed 18 h after each exposure, and cells and fluid analyzed. The BAL fluid of volunteers exposed to 0.10 ppm ozone had significant increases in neutrophils (PMNs), protein, PGE2, fibronectin, interleukin-6 (IL-6), and lactate dehydrogenase (LDH) compared with BAL fluid from the same volunteers exposed to filtered air. The study concludes that exposure of humans to low levels of ozone is sufficient to initiate an inflammatory reaction in the lung.
||Pub. in American Jnl. of Respiratory, Cellular, and Molecular Biology, v4 p72-81 Jan 91. Prepared in cooperation with North Carolina Univ. at Chapel Hill. School of Medicine, and ABB Environmental Services, Inc., Chapel Hill, NC.
|NTIS Title Notes
||Reprint: Exposure of Humans to Ambient Levels of Ozone for 6.6 Hours Causes Cellular and Biochemical Changes in the Lung.
||68A; 68G; 57B; 57Y
||PC A03/MF A01