Main Title |
Chlorobenzene-Impaired Lindane Metabolism and the Effect of Pretreatment with Chlorobenzene, Lindane, or Chlorobenzene Plus Lindane. |
Author |
Chadwick, R. W. ;
Copeland, M. F. ;
Froehlich, R. ;
Cooke, N. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA-600/J-83-208; |
Stock Number |
PB84-205160 |
Additional Subjects |
Pesticides ;
Toxicology ;
Chlorine organic compounds ;
Rats ;
Laboratory animals ;
Dosage ;
Reprints ;
Lindane ;
Cyclohexane/hexachloro ;
Chlorobenzene
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-205160 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
The storage and metabolism of lindane (r-HCH) was studied in the female rat after the administration of a hepatotoxic dose of chlorobenzene. Impaired lindane metabolism was observed following a challenge dose of 1.12g chlorobenzene/kg. The data indicated that a hepatotoxic dose of chlorobenzene (CB) selectively impaired certain pathways, such as dehydrochlorination and the direct hydroxylation of lindane, to a greater extent than others, such as the dehydrogenation and dechlorination of lindane. Pretreatment with a subtoxic level of chlorobenzene produced: (1) significant increases in the dehydrogenation of lindane, (2) significant increase in the excretion of metabolites derived from the dehydrogenation of lindane through hexachlorocylohexene, r-HCCH, (4) significant improvement in the excretion of metabolites derived from CB-impaired dehydrochlorination of lindane as well as from the CB-impaired hydroxylation of lindane, and (5) significant reduction in the level of unaltered lindane stored in the adipose tissue. |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, 12 p599-610 1983. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Chlorobenzene-Impaired Lindane Metabolism and the Effect of Pretreatment with Chlorobenzene, Lindane, or Chlorobenzene Plus Lindane. |
PUB Date Free Form |
1983 |
Category Codes |
6T; 57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
424418142 |
Origin |
NTIS |
Type |
CAT |