Main Title |
Chlordimeform Produces Profound, Selective, and Transient Changes in Visual Evoked Potentials of Hooded Rats. |
Author |
Boyes, W. K. ;
Dyer, R. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA/600/J-84/258; |
Stock Number |
PB85-192961 |
Additional Subjects |
Toxicity ;
Pesticides ;
Insecticides ;
Acaricides ;
Chlorine organic compounds ;
Visual perception ;
Rats ;
Laboratory animals ;
Formamidines ;
Chlordimeform ;
Dose rate ;
Electric stimulation
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-192961 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
17p |
Abstract |
Rat visual function was tested after acute exposure to chlordimeform (CDM), a formamidine insecticide/acaricide. Adult male Long-Evans rats were surgically implanted with epidural recording electrodes overlying visual cortex and tested 1 week later. Pattern reversal-evoked potentials (PREPs), flash-evoked potentials (FEPs), and FEP recovery ratios were measured after acute CDM administration. In the first study, which examined dose-response relationships, i.p. injections of 0 (saline), 5, 15, or 40 mg/kg CDM-HCl were administered 30 min prior to testing. In the second study, which examined the time course of CDM action, PREPs and paired-pulse FEPs were recorded 3, 6, and 24 h after dosage with either 0 or 40 mg/kg CDM. In summary, acute exposure to CDM temporarily increased both the amplitude and latency of PREPs, but only the latency of FEPs. |
Supplementary Notes |
Pub. in Experimental Neurology 86, p434-447 1984. |
NTIS Title Notes |
Journal article. |
PUB Date Free Form |
1984 |
Category Codes |
6T; 6F; 6C; 57Y; 57Z; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
518921034 |
Origin |
NTIS |
Type |
CAT |