||Multiresidue Procedure for Halo- and Nitrophenols. Measurement of Exposure to Biodegradable Pesticides Yielding these Compounds as Metabolites.
Shafik, Talaat M. ;
Sullivan, Hazel C. ;
Enos., Henry R. ;
||Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
||PB-276 901, PB-276 897
Chemical analysis ;
Halogen organic compounds ;
Laboratory animals ;
Gas chromatography ;
Electron capture ;
Electron capture gas chromatography
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The urinary level of phenolic compounds may be the key for establishing an index of exposure to pesticides containing this moiety as an easily hyrolyzed or metabolized portion of the molecule. A method has been developed for quantitating ten halo- and nitrophenols in rat urine which could result from exposure to and subsequent metabolism and excretion of a broad spectrum of pesticides. The procedure involves acid hydrolysis, extraction, derivatization, silica gel chromatography, and electron-capture gas chromatography. Male rats fed pesticidal compounds containing halo- and nitrophenol moieties at levels varying from factors of 0.00001 to 0.01 of the LD50 were used to establish the usefulness of this procedure for determining the extent of exposure to the biodegradable pesticides.
||found in PB-276 897 titled: Journal articles on pesticide chemical analysis. Group 5.
||Pub. in Agricultural and Food Chemistry, v21 n2 p295-298, Mar/Apr 73.
||Included in the report, Journal Articles on Pesticide Chemical Analysis. Group 5, PB-276 897.
||Reprint: Multiresidue Procedure for Halo- and Nitrophenols. Measurement of Exposure to Biodegradable Pesticides Yielding these Compounds as Metabolites,
|PUB Date Free Form
||7D; 6F; 6E; 68E; 57P; 57D; 99A
||(Order as PB-276 897, MF A01)