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OLS Field Name OLS Field Data
Main Title Aromatase Inhibitors [electronic resource] /
Type EBOOK
Author Furr, Barrington J.A.
Publisher Birkhäuser Basel,
Year Published 2006
Call Number RC261-271
ISBN 9783764374181
Subjects Medicine. ; Oncology. ; Toxicology. ; Internal medicine. ; Cytology.
Internet Access
Description Access URL
http://dx.doi.org/10.1007/3-7643-7418-7
Collation IX, 182 p. 30 illus. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes Background and development of aromatase inhibitors -- Aromatase inhibitors and models for breast cancer -- Clinical pharmacology of aromatase inhibitors -- Clinical studies with exemestane -- Clinical studies with letrozole -- Clinical studies with anastrozole -- The third-generation aromatase inhibitors: a clinical overview -- Lessons from the ArKO mouse -- Possible additional therapeutic uses of aromatase inhibitors. Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Place Published Basel
Corporate Au Added Ent SpringerLink (Online service)
Title Ser Add Ent Milestones in Drug Therapy MDT
Host Item Entry Springer eBooks
PUB Date Free Form 2006
Series Title Untraced Milestones in Drug Therapy MDT
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20130725165747
Language eng
Origin SPRINGER
Type EBOOK
OCLC Rec Leader 03048nam a22005055i 45