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RECORD NUMBER: 274 OF 350

Main Title Signaling Pathways in Squamous Cancer [electronic resource] /
Type EBOOK
Author Glick, Adam B.
Other Authors
Author Title of a Work
Waes, Carter Van.
Publisher Springer New York,
Year Published 2011
Call Number RC261-271
ISBN 9781441972033
Subjects Medicine ; Oncology ; Toxicology
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-1-4419-7203-3
Collation XX, 462 p. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV light, tobacco smoke, and infectious agents. Consequently, squamous cell carcinomas that form in these tissues are among the most common human solid tumors, and have high morbidity and mortality. The signaling pathways that regulate epithelial homeostasis and the alterations in these pathways that arise during cancer development share certain features among these different tissue sites. This book brings together timely reviews from experts in the field on mechanisms and signaling pathways such as EGFR, TGF1, NFB, PPARs and mTOR/AKT that regulate development of squamous cancer in both human and experimental mouse models, with a focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy. This comprehensive monograph will be important for researchers wishing to enter the field, for medical students, and for established basic and clinical investigators who would gain from an overview of the field.
Place Published New York, NY
Corporate Au Added Ent SpringerLink (Online service)
Host Item Entry Springer eBooks
PUB Date Free Form 2011
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20141130022943
Language eng
Origin SPRINGER
Type EBOOK
OCLC Rec Leader 02628nam a22004215i 45