| Main Title |
Metastasis of Prostate Cancer [electronic resource] / |
| Type |
EBOOK |
| Author |
Ablin, Richard J.
|
| Other Authors |
|
| Publisher |
Springer Netherlands, |
| Year Published |
2007 |
| Call Number |
RC261-271 |
| ISBN |
9781402058479 |
| Subjects |
Medicine ;
Oncology
|
| Internet Access |
|
| Collation |
XIV, 407 p. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows. |
| Place Published |
Dordrecht |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Title Ser Add Ent |
Cancer Metastasis - Biology and Treatment, 10 |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2007 |
| Series Title Untraced |
Cancer Metastasis - Biology and Treatment, 10 |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20141124021251 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
02890nam a22004215i 45 |
