| Main Title |
NF-kB in Health and Disease [electronic resource] / |
| Type |
EBOOK |
| Author |
Karin, Michael.
|
| Publisher |
Springer Berlin Heidelberg, |
| Year Published |
2011 |
| Call Number |
RC261-271 |
| ISBN |
9783642160172 |
| Subjects |
Medicine ;
Oncology
|
| Internet Access |
|
| Collation |
VIII, 268 p. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
Preface -- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms -- IKK regulation and human genetics -- Specialized chromatin patterns in the control of inflammatory gene expression -- Macrophages and NF-kappaB in Cancer -- NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster -- IKK and NF-kappaB mediated functions in carcinogenesis -- Control of NF-kappaB activity by proteolysis -- NF-kappaB as a target for oncogenic viruses -- NF-kappaB and Innate Immunity -- Inhibition of NF-kappaB signaling as a strategy in disease therapy -- NF-κB and mucosal homeostasis -- NF-kappaB In liver cancer - the plot thickens -- Subject index. This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system. |
| Place Published |
Berlin, Heidelberg |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Title Ser Add Ent |
Current Topics in Microbiology and Immunology, 349 |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2011 |
| Series Title Untraced |
Current Topics in Microbiology and Immunology, 349 |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20130725205959 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
02984nam a22004215i 45 |
