Main Title |
Metabolism of Octamethylcyclotetrasiloxane in the Monkey with Attachments and Cover Letter Dated 05/21/1988. |
CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1988 |
Report Number |
86-880000257 |
Stock Number |
OTS0514147 |
Additional Subjects |
Toxicology ;
Health effects ;
Octamethylcyclotetrasiloxane (556-67-2) ;
Pharmaco Kinetics ;
Mammals ;
Monkeys ;
Oral ;
Diet ;
Toxic substances ;
Laboratory animals ;
CAS No 556-67-2
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0514147 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
23p |
Abstract |
The absorption, distribution, metabolism and elimination of octamethylcyclotetrasiloxane were investigated in 2 monkeys administeredsingle oral doses at a level of 50 mg/kg. The C14-labeled test article was distributed throughout the body and it was absorbed mainly from the gastrointestinal tract. Residual 14C tissue levels 240 hours after oral dosing in microgram/gm equiv. were the following; 3.6 in lymph node, 8.4in mesentery, 13.1 in fat and 5.3 in liver. The major portion of radioactivity excreted was found in the urine with total recoveries of C14 at 63% and 52% while fecal recoveries were 11% and 16% of C14. Threemetabolites were observed; dimethylsilanediol, tetramethyl-1,3-disiloxane diol and hexamethyl-1,5-trisiloxane diol. Themetabolism closely paralled that of 2,6-cis and 2,6-trans-diphenylhexame thylcyclotetrasiloxane. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
1988 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028801920 |
Origin |
NTIS |
Type |
CAT |