Main Title |
Computer Automated Structure Evaluation of the Carcinogenicity of N-Nitrosothiazolidine and N-Nitrosothiazolidine 4-Carboxylic Acid. |
Author |
Rosenkranz, H. S. ;
Klopman, G. ;
|
CORP Author |
Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1987 |
Year Published |
1987 |
Report Number |
EPA-R-812264; EPA/600/J-88/406; |
Stock Number |
PB90-111584 |
Additional Subjects |
Amines ;
Nitroso compounds ;
Toxicity ;
Reprints ;
Computer automated structure evaluation(CASE) ;
Carcinogenicity tests ;
N-Nitrosothiazolidine ;
N-Nitrosothiazolidine-4-carboxylic acid ;
Predictive value of tests ;
Structure-activity relationship
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-111584 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
N-Nitrosothiazolidine 4-carboxylic acid (NTCA), a sulphur-containing nitrosamine present in human urine, was predicted to be non-carcinogenic by CASE, the newly developed Computer Automated Structure Evaluating system. On the other hand, N-nitrosothiazolidine (NTHZ), a nitrosamine present in food products, was predicted to be carcinogenic. The putative non-carcinogenic NTCA may be metabolized to NTHZ, a predicted carcinogen. (Copyright (c) 1987 Pergamon Journals Ltd.) |
Supplementary Notes |
Pub. in Fd. Chem. Toxic. v25 n3 p253-256 1987. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Computer Automated Structure Evaluation of the Carcinogenicity of N-Nitrosothiazolidine and N-Nitrosothiazolidine 4-Carboxylic Acid. |
Category Codes |
57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
935218817 |
Origin |
NTIS |
Type |
CAT |