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RECORD NUMBER: 304 OF 526

OLS Field Name OLS Field Data
Main Title Interactions of various pollutants on causation of pulmonary disease /
Author Ehrlich, Richard,
Other Authors
Author Title of a Work
Ehrlich, Richard,
Gardner, Donald E.,
CORP Author IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA-600/1-78-057; EPA-68-02-2274
Stock Number PB-288 363
OCLC Number 52473331
Subjects Air--Pollution--Health aspects. ; Pollutants--Health aspects.
Additional Subjects Respiratory diseases ; Toxicology ; Streptococcus ; Air pollution ; Interactions ; Exposure ; Infectious diseases ; Resistance ; Public health ; Mice ; Bacteria ; Pneumonia ; Enzymes ; Concentration(Composition) ; Nitrogen dioxide ; Ozone ; Tolerances(Physiology) ; Sulfur dioxide ; Ammonium sulfate ; Zinc sulfates ; Recommendations ; Experimental data ; Laboratory animals ; Toxic substances ; Infections ; Air pollution effects(Humans) ; Synergism ; Animal models ; Streptococcus pyogenes ; Environmental health
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=91013XR1.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJBD ARCHIVE EPA 600-1-78-057 Headquarters Library/Washington,DC 04/28/2014
EJBD  EPA 600-1-78-057 c.1 Headquarters Library/Washington,DC 06/09/2014
EKBD  EPA-600/1-78-057 Research Triangle Park Library/RTP, NC 06/20/2003
ELBD RPS EPA 600-1-78-057 repository copy AWBERC Library/Cincinnati,OH 04/16/2018
NTIS  PB-288 363 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation x, 49 pages : illustrations ; 28 cm
Abstract Studies were conducted to determine the effects of single and multiple exposures to individual and pollutant mixtures on resistance to respiratory infections. Results of NO2 studies indicate the greater importance of short-term peak concentrations than prolonged exposures to lower concentrations in increasing the susceptibility to infections. Single 3-hr exposure to mixtures containing various concentrations of NO2 and O3 had an additive effect. Repeated 3-hr exposures for 4 weeks to mixtures consisting of 3760 micrograms/cu m NO2 and 98 micrograms/cu m O3 suggested a synergistic interaction between the two pollutants. Daily 3-hr exposures for 6 months to mixtures of 940 micrograms/cu m NO2 and 196 micrograms/cu m O3 resulted in significant excess mortality, and reduced mean survival time in infected animals. Continuation of exposure to the pollutants for 14 days after the infectious challenge resulted in a pronounced increased susceptibility to the respiratory infection, after 1, 2 or 3 month exposure. In non-infected mice this exposure regimen induced changes in the activity of several serum enzymes.
Notes Project Officer: Donald E. Gardner. IIT Research Institute Contract Number: 68-02-2274 "August 1978." "EPA-600/1-78-057." Includes bibliographical references.
Place Published Research Triangle Park, N.C.
Access Notes Also available via the World Wide Web.
Corporate Au Added Ent United States. Environmental Protection Agency.; United States. Environmental Protection Agency. Office of Research and Development.; Health Effects Research Laboratory (Research Triangle Park, N.C.); IIT Research Institute.
PUB Date Free Form 1978
NTIS Prices PC A04/MF A01
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
OCLC Time Stamp 20180328112711
Language eng
Origin OCLC
Type MERGE
OCLC Rec Leader 01954cam 2200469Ka 45010