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OLS Field Name OLS Field Data
Main Title Integration of Species Sensitivity and Dosimetry Data in the Extrapolation of Ozone and Nitrogen Dioxide Health Data from Animal to Man.
Author Graham, J. A. ; Hatch, G. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-600/D-84-125;
Stock Number PB84-195312
Additional Subjects Ozone ; Nitrogen dioxide ; Sensitivity ; Dosimetry ; Animals ; Humans ; Lung ;
Library Call Number Additional Info Location Last
NTIS  PB84-195312 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 14p
Abstract Estimations of regional pulmonary doses of O3 and NO2 need to be combined with an understanding of the sensitivity of several animal species and man to equivalent tissue doses before animal to man quantitative extrapolations can be performed. Because of potential species differences in anti-oxidant defenses and repair mechanisms it is unlikely that regional lung dose-response effects will be identical across species. These differences will be discussed and unifying concepts presented that are likely to quantitatively accomodate the differences in eventual extrapolation modeling. The concepts and their current state of experimental or theoretical validation to be addressed include the application of (1) scaling principles between species following in vitro and in vivo exposure, (2) the parallelogram concept which directly relates acute animal to acute human effects and acute animal to chronic animal effects, thereby permitting the indirect estimation of chronic human effects, and (3) species comparisons of the health effects of O3.
PUB Date Free Form May 84
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 423019824
Origin NTIS
Type CAT