||Comparison of Biochemical Effects of Nitrogen Dioxide, Ozone and Their Combination in Mouse Lung. 1. Intermittent Exposures.
Mustafa, M. G. ;
Elsayed, N. M. ;
von Dohlen, F. M. ;
Hassett, C. M. ;
Postlehwait, E. M. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Los Angeles. ;Northrop Services, Inc., Research Triangle Park, NC.
Nitrogen dioxide ;
Physiological effects ;
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Swiss Webster mice were exposed to either 4.8 ppm (9024 micrograms/cu.m.) nitrogen dioxide (NO2), 0.45 ppm (882 micrograms/cu.m.) ozone (O3), or their combination intermittently (8 hr daily) for 7 days, and the effects were studied in the lung by a series of physical and biochemical parameters, including lung weight, DNA and protein contents, oxygen consumption, sulfhydryl metabolism, and activities of NADPH generating enzymes. The results show that exposure to NO2 caused relatively smaller changes than O3, and that the effect of each gas alone under the conditions of exposure was not significant for most of the parameters tested. However, when the two gases were combined, the exposure caused changes that were greater and significant. Statistical analysis of the data shows that the effects of combined exposure were more additive, i.e., they might be synergistic. The observations suggest that intermittent exposure to NO2 or O3 alone at the concentration used may not cause significant alterations in lung metabolism, but when the two gases are combined the alterations may become significant.
||Pun. in Toxicology and Applied Pharmacology 72, p82-90 1984. Prepared in cooperation with California Univ., Los Angeles, CA., and Northrop Services, Inc., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Comparison of Biochemical Effects of Nitrogen Dioxide, Ozone and Their Combination in Mouse Lung. 1. Intermittent Exposures.
|PUB Date Free Form
||6T; 6A; 57Y; 57B
||Not available NTIS