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OLS Field Name OLS Field Data
Main Title Neonatal Sympathectomy Compromises Development of Responses of Ornithine Decarboxylase to Hormonal Stimulation in Peripheral Tissues.
Author Hou, Q. C. ; Eylers, J. P. ; Lappi, S. E. ; Kavlock, R. J. ; Slotkin, T. A. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-R-813769; EPA/600/J-89/380;
Stock Number PB90-216193
Additional Subjects Hormones ; Kidney ; Heart ; Lung ; Angiotensin ; Vasopressin ; Graphs(Charts) ; Reprints ; Chemical sympathectomy ; Ornithine decarboxylase ; Newborn animals ; Denervation ; Hydroxydopamines
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NTIS  PB90-216193 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 6p
Abstract The onset of sympathetic innervation has been shown to play a role in the development of postsynaptic reactivity to stimulation. In the current study, whether this relationship extends to responses evoked by hormonal stimuli was examined. Rats denervated at birth by 6-hydroxydopamine treatment showed an impaired ability of vasopressin or angiotensin to stimulate cardiac ornithine decarboxylase activity. In the kidney, responsiveness was affected only for vasopressin and in the lung denervation had only transient effects on the hormonal responses. The results confirm that sympathetic input is required for proper development of some, but not all hormonal responses; the tissue specificity suggests a role of neural factors selective for cardiac development. (Copyright (c) Oxford University Press 1989.)
Supplementary Notes Pub. in Jnl. of Development Physiology, v12 p189-192 1989. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Neonatal Sympathectomy Compromises Development of Responses of Ornithine Decarboxylase to Hormonal Stimulation in Peripheral Tissues.
Category Codes 57S; 57B
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 018016148
Origin NTIS
Type CAT