||Neonatal Exposure to Trimethyltin Disrupts Spatial Delayed Alternation Learning in Preweanling Rats.
Stanton, M. E. ;
Jensen, K. F. ;
Pickens, C. V. ;
||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;NSI Technologies, Inc., Research Triangle Park, NC.
Trimethyltin compounds ;
Learning disorders ;
Central nervous system ;
Newborn animals ;
Dose-response relationships ;
Analysis of variance ;
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||Trimethyltin is an organotin compound that produces potent neurotoxicity in both adult and developing animals. The limbic system is a primary CNS target site for this toxicity and a prominent behavioral effect of TMT is disruption of learning and memory. Impairment of cognitive development has also been suggested by studies showing that rats neonatally exposed to TMT cannot perform spatial working memory tasks during adulthood. However, the question of how early in ontogeny such deficits can be detected has not been addressed. The present study examined the question with a T-maze delayed alternation learning paradigm. Long-Evans rat pups, injected i.p. on postnatal day 10 (PND10) with 6 mg/kg TMT and tested on PND18, were unable to learn delayed alternation in the manner shown by vehicle control pups. However, TMT- and vehicle-treated groups were both able to learn a simple position discrimination. These findings indicate a selective impairment of spatial working memory by neonatal TMT exposure and show that the impairment can be demonstrated during the preweanling period in the rat.
||Pub. in Neurotoxicology and Teratology, v13 p525-530 Oct 91. See also PB91-171793. Prepared in cooperation with NSI Technologies, Inc., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Neonatal Exposure to Trimethyltin Disrupts Spatial Delayed Alternation Learning in Preweanling Rats.
||PC A02/MF A01