Main Title |
Human Upper Respiratory Tract Responses to Inhaled Pollutants with Emphasis on Nasal Lavage. |
Author |
Koren, H. S. ;
Devlin, R. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-93/120; |
Stock Number |
PB93-181089 |
Additional Subjects |
Air pollution effects(Humans) ;
Respiratory system ;
Nose(Anatomy) ;
Indoor air pollution ;
Signs and symptoms ;
Neutrophils ;
Inflammation ;
Reprints ;
Nasal lavage ;
Sick buildings ;
Volatile organic compounds
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-181089 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
A set of symptoms has been described during the past two decades which has been called the 'sick building syndrome'. These symptoms include eye, nose, and throat irritation; headache; mental fatigue; and respiratory distress. It is likely that volatile organic compounds (VOC) present in synthetic materials used in homes and office buildings contribute to these symptoms. However, there have been few studies in which humans have been exposed to known amounts of VOC under carefully controlled conditions. In the study 14 subjects have been exposed to a mixture of VOC (25 mg/cu m total hydrocarbon) representative of what is found in new homes and office buildings. Since irritation of the nose and throat are symptoms often associated with the upper respiratory tract and may result from an inflammatory response in the upper airways, the authors have used nasal lavage to monitor neutrophil (PMN) influx into the nasal passages following exposure to VOC. The authors report statistically significant increases in PMNs both immediately after a four hour exposure to VOC, as well as 18 hours later. |
Supplementary Notes |
Pub. in Annals of the New York Academy of Sciences 41, p215-224 Nov 92. See also PB91-115881. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Human Upper Respiratory Tract Responses to Inhaled Pollutants with Emphasis on Nasal Lavage. |
Category Codes |
68G; 68A; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
316134241 |
Origin |
NTIS |
Type |
CAT |