||Neurotoxicity of Parathion-Induced Acetylcholinesterase Inhibition in Neonatal Rats.
Veronesi, B. ;
Pope, C. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northeast Louisiana Univ., Monroe. Toxicology Program.
Cholinesterase inhibitors ;
Newborn animals ;
Electron microscopy ;
Dose-response relationships ;
Chemical depression ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The biochemical and morphological neurotoxic effects of postnatal acetylcholinesterase (AChE) inhibition were examined in rat pups dosed with parathion, at time points critical to hippocampal neurogenesis and synaptogenesis (i.e., D5-20). Hippocampal cytopathology as assessed by light and electron microscopy, consisted of cellular disruption and necrosis in the DG, CA4, and CA3a regions. Synaptic disruption in the DG molecular layer was suggested by histochemical preparation using both the Timm's and AChE stains. In parathion-treated D12 pups, hippocampal AChE was depressed 70% and QNB binding depressed by 36%. The above results indicated that definite neurotoxic consequences are associated with persistent AChE depression in the neonatal rat.
||Pub. in NeuroToxicology, v11 n4 p609-626 Dec 90. Prepared in cooperation with Northeast Louisiana Univ., Monroe. Toxicology Program.
|NTIS Title Notes
||Reprint: Neurotoxicity of Parathion-Induced Acetylcholinesterase Inhibition in Neonatal Rats.
||57Y; 57F; 68E
||PC A03/MF A01