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OLS Field Name OLS Field Data
Main Title Mechanisms Underlying Somatosensory Cortical Dynamics: 2. In vitro Studies.
Author Lee, C. J. ; Whitsel, B. L. ; Tommerdahl, M. ;
CORP Author North Carolina Univ. at Chapel Hill. Dept. of Psychology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA-R-818321010; EPA/600/J-92/376;
Stock Number PB93-107225
Additional Subjects Somatosensory cortex ; Neurons ; Neurophysiology ; In vitro analysis ; Evoked potentials ; Electric stimulation ; Rats ; Deoxyglucose ; Metabolism ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-107225 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1993
Collation 29p
Abstract The response of the sensorimotor cortical slice to repetitive, single site afferent drive is mapped using both evoked potential and metabolic mapping (2DG) methods. Systematic changes (increases or decreases) in the evoked potential occur during repetitive 3-5 Hz stimulation. Place, timing, and intensity of repetitive stimulation influence the amplitude and form of the response alterations observed at a given cortical locus. The neuron populations which exhibit different response modifications to the same repetitive stimulus are distributed non-randomly in the slice: neurons occupying column-shaped aggregates undergo a common response alteration (either an increase or decrease) during repetitive stimulation, with sharp boundaries separating neighboring aggregates distinguishable on the basis of their dynamic behaviors. The distribution of stimulus-evoked 2DG uptake in the slice is columnar, the dimensions of the 2DG columns corresponding to those mapped with neurophysiological methods. Taken together, the findings support the concept (Whitsel et al., 1991) that repetitive stimulation causes the intrinsic network of somatosensory cortex to dynamically modify the network's response to extrinsic excitatory drive so that the local differences in the pattern of extrinsic excitatory drive to neighboring cortical columns are enhanced.
Supplementary Notes Pub. in Cerebral Cortex Jnl. v2 n2 p107-133 Mar/Apr 92. See also PB93-107217. Color illustrations reproduced in black and white. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Mechanisms Underlying Somatosensory Cortical Dynamics: 2. In vitro Studies.
Category Codes 57I; 57S
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 234225656
Origin NTIS
Type CAT