||Effects of Selenium on 7,12-Dimethylbenz(a)anthracene-Induced Mammary Carcinogenesis and DNA Adduct Formation.
Ip, C. ;
Daniel, F. B. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Roswell Park Memorial Inst., Buffalo, NY.
Deoxyribonucleic acids ;
Malignant neoplasms ;
Public health ;
Human nutrition ;
Laboratory animals ;
Chemical analysis ;
Environmental health ;
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||The purpose of the present investigation was to determine the effects of dietary selenium deficiency or excess on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary neoplasia in rats and to delineate whether selenium-mediated modification of mammary carcinogenesis was associated with changes in carcinogen: DNA adduct formation and activities of liver microsomal enzymes that are involved in xenobiotic metabolism. Results of this experiment indicated that selenium deficiency enhanced mammary carcinogenesis only when this nutritional condition was maintained in the postinitiation phase. Likewise, an excess of selenium intake inhibited neoplastic development only when this regimen was continued after DMBA administration. In either case, deficient or excess selenium at the time of carcinogenic insult failed to produce a significant effect on subsequent tumor yield, if selenium intake was returned to normal during the proliferative phase of tumor growth. Based on the results of these studies, it is suggested that selenium-mediated modification of mammary tumorigenesis is not exerted via alterations in carcinogenic initiation (i.e., metabolism or DNA adduct formation).
||Prepared in cooperation with Roswell Park Memorial Inst., Buffalo, NY.
||Pub. in Cancer Research, v45 p61-65 Jan 85.
|NTIS Title Notes
||Reprint: Effects of Selenium on 7,12-Dimethylbenz(a)anthracene-Induced Mammary Carcinogenesis and DNA Adduct Formation.
|PUB Date Free Form
||6T; 6E; 7D; 57Y; 57U; 68G; 99A
||Not available NTIS