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RECORD NUMBER: 359 OF 1147

OLS Field Name OLS Field Data
Main Title Effect of the Age of B6C3F1 Mice on Phenobarbital Promotion of Diethylnitrosamine Initiated Liver Tumors.
Author Klaunig, J. E. ; Weghorst, C. M. ; Pereira, M. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Medical Coll. of Ohio at Toledo. Dept. of Pathology.
Year Published 1987
Report Number EPA/600/J-87/276;
Stock Number PB88-185533
Additional Subjects Liver neoplasms ; Nitroso compounds ; Phenobarbital ; Carcinogens ; Mice ; Aging(Biology) ; Adenoma ; Reprints ; Diethylnitrosamine ; Cocarcinogenesis
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NTIS  PB88-185533 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 9p
Abstract Chronic exposure to phenobarbital (PB) in the drinking water of male B6C3F1 mice starting at 4 weeks of age and subsequent to a single (ip) injection of diethylnitrosamine (DENA) administered on Day 15 of age has been shown to result in the inhibition of hepatic tumor formation. In the study, the authors varied the time of onset of PB administration to determine if sexual maturity would affect liver tumor formation and progression. Data from the study suggest that the inhibition of hepatocellular tumorigenesis by PB remains intact even when the start of the administration of PB is withheld up to 12 weeks of age. (Copyright (c) 1987 Academic Press, Inc.)
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v90 n1 p79-85 Aug 87. Prepared in cooperation with Medical Coll. of Ohio at Toledo. Dept. of Pathology.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of the Age of B6C3F1 Mice on Phenobarbital Promotion of Diethylnitrosamine Initiated Liver Tumors.
PUB Date Free Form c1987
Category Codes 57E; 57Q; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 816223028
Origin NTIS
Type CAT