||Effect of Subsequent Treatment of Chloroform of Phenobarbital on the Incidence of Liver and Lung Tumors Initiated by Ethylnitrosourea in 15 Day Old Mice.
Pereira, M. A. ;
Herren-Freund, S. L. ;
Knutsen, G. L. ;
||Health Effects Research Lab., Cincinnati, OH. ;Pathology Associates, Inc., Frederick, MD.
Laboratory animals ;
Liver neoplasms ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The effect of subsequent administration of chloroform or phenobarbital on the incidence of ethylnitrosourea (ENU) initiated liver and lung tumors was investigated. Fifteen day old Swiss mice were administered ENU, and at weaning they started to receive either 1800 ppm chloroform or 500 ppm sodium phenobarbital in their drinking water. The mice continued to receive either chloroform or phenobarbital until they were sacrificed at 52 weeks of age. ENU at 5 and 20 mg/kg, caused a dose-dependent increase in liver and lung tumors. The male mice were more sensitive to the induction of liver tumors, while no sex preference was observed for the induction of lung tumors. In male mice chloroform inhibited, while in female and male mice phenobarbital promoted spontaneous and ENU-induced liver tumors. Neither subsequent treatment with chloroform nor phenobarbital affected the incidence of ENU-induced lung tumors. When administered in the drinking water, chloroform is an inhibitor while phenobarbital is a promoter of hepatocarcinogenesis in mice. (Copyright (c) IRL Press Ltd., Oxford, England.)
||Prepared in cooperation with Pathology Associates, Inc., Frederick, MD.
||Pub. in Carcinogenesis, v6 n2 p203-207 Feb 85.
|NTIS Title Notes
|PUB Date Free Form
||6T; 6E; 57Y; 57E
||Not available NTIS