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RECORD NUMBER: 355 OF 1146

OLS Field Name OLS Field Data
Main Title Effect of Phenobarbital on Diethylnitrosamine and Dimethylnitrosamine Induced Hepatocellular Tumors in Male B6C3F1 Mice.
Author Klaunig, J. E. ; Weghorst, C. M. ; Pereira, M. A. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/381;
Stock Number PB90-103169
Additional Subjects Toxicity ; Liver neoplasms ; Phenobarbital ; Carcinogens ; Mice ; Males ; Body weight ; Reprints ; Diethylnitrosamine ; Dimethylnitrosamine ; Dose-response relationships ; Drinking water ; Organ weight
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NTIS  PB90-103169 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/1990
Collation 9p
Abstract The effect of the type of carcinogen initiator on the ability of phenobarbital to promote hepatic tumor formation in 15-day-old initiated male B6C3F1 mice was evaluated. Fifteen day old male B6C3F1 mice were divided into 6 groups of 10 mice each. Groups 1 and 2 received a single intraperitoneal (ip) injection of diethylnitrosamine (DENA) (5 micro g/gbw). Groups 3 and 4 received a single ip injection of dimethylnitrosamine (DMNA) (5 micro g/gbw). Groups 5 and 6 received a single ip injection of saline. At weaning (28 days of age), mice in groups 2, 4, and 6 received phenobarbital (500 mg/ml) in their drinking water. Mice in groups 1, 3, and 5 received deionized drinking water. Drinking water treatment continued for 24 weeks at which time mice were sampled. At sampling, mice were examined for hepatic tumors by histology. Mice in Groups 5 (no treatment) and 6 (PB only) did not exhibit hepatic tumors. Groups 2 (DENA + PB) displayed a decrease in hepatic adenomas from that of Group 1 (DENA only) confirming previous observations. Treatment with DMNA and PB (Group 4) resulted in a significant increase in both hepatic adenoma incidence and number over that of DMNA only (Group 3) treated mice. (Copyright (c) 1988 Elsevier Scientific Publishers, Ireland Ltd.)
Supplementary Notes Pub. in Cancer Letters, v42 p133-139 Sep 88. Prepared in cooperation with Medical Coll. of Ohio at Toledo.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of Phenobarbital on Diethylnitrosamine and Dimethylnitrosamine Induced Hepatocellular Tumors in Male B6C3F1 Mice.
Category Codes 57Y; 57E; 68G
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 935215972
Origin NTIS
Type CAT