||Comparison of the Lung Adenoma Response in Strain A/J Mice after Intraperitoneal and Oral Administration of Carcinogens.
Stoner, G. D. ;
Greisiger, E. A. ;
Schut, H. A. J. ;
Pereira, M. A. ;
Loeb, T. R. ;
||Medical Coll. of Ohio at Toledo.;Health Effects Research Lab., Cincinnati, OH.
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||This study was undertaken to compare the ability of a series of compounds from different chemical classes to induce lung tumors in strain A/J mice after either ip or po administration. 3-Methylcholanthrene, benzo(a)pyrene, urethan, diethylnitrosamine, ethylnitrosourea, and dimethylhydrazine induced a significant(p<0.05; t test)increase in the lung tumor response when given both ip and po. 2,4-Dinitrotoluene, 2,6-dinitrotoluene, and a 2:1 mixture of 2,4-dinitrotoluene and 2,6-dinitrotoluene were inactive by both routes of administration and at all dose levels. The lung tumor response to all doses of 3-methylcholanthrene and benzo(a)pyrene, the highest dose of diethylnitrosamine, and the middle doses of both ethylnitrosourea and dimethylhydrazine varied as a function of the route of administration.
||Pub. in Toxicology and Applied Pharmacology, v72 p313-323 1984.
|NTIS Title Notes
||Reprint: Comparison of the Lung Adenoma Response in Strain A/J Mice after Intraperitoneal and Oral Administration of Carcinogens.
|PUB Date Free Form
||6T; 6E; 57Y; 57O
||Not available NTIS