||Comparison of Rat Liver Foci Assay and Strain a Mouse Lung Tumor Assay to Detect Carcinogens: A Review.
Pereira, M. A. ;
Stoner, G. D. ;
||Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo.
Malignant neoplasms ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||A comparison was performed of the results reported in the literature of chemicals tested in the rat liver foci assay and/or in the strain A lung tumor assay to the results of the chemicals in long-term carcinogenicity bioassays. The rat liver foci assay was sensitive to 69% of 54 compounds found to be carcinogenic in long-term bioassays and the strain A lung tumor assay to 54% of 93 carcinogens. None of the ten compounds found to be noncarcinogenic in long-term bioassays were active in the rat liver foci assay, while seven of 23 non-carcinogens (30%) were active in the lung tumor assay. Ten of the 16 carcinogens negative in the rat liver foci assay are believed to be tumor promoters; 3 are direct-acting alkylating agents (dimethylsulfate, epichlorohydrin, and beta-propiolactone); and the remaining 4 are azobenzene, 1,2-dibromoethane, oxazepam and thioacetamide.
||Prepared in cooperation with Medical Coll. of Ohio at Toledo.
||Pub. in Fundamental and Applied Toxicology 5, p688-699 1985.
|NTIS Title Notes
||Reprint: Comparison of Rat Liver Foci Assay and Strain a Mouse Lung Tumor Assay to Detect Carcinogens: A Review.
|PUB Date Free Form
||6T; 6E; 57Y; 57O
||Not available NTIS