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RECORD NUMBER: 289 OF 1145

OLS Field Name OLS Field Data
Main Title Comparative Potency Method for Cancer Risk Assessment: Application to the Quantitative Assessment of the Contribution of Combustion Emissions to Lung Cancer Risk.
Author Lewtas, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/238;
Stock Number PB86-116415
Additional Subjects Malignant neoplasms ; Combustion products ; Emissions ; Bioassay ; Polycyclic compounds ; Soot ; Comparison ; Risk assessments ; Humans ; Quantitative analysis ; Mutagenesis ; Cancer
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-116415 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract Combustion sources emit soot particles containing carcinogenic polycyclic organic compounds which are mutagenic in short-term genetic bioassays in microbial and mammalian cells and are tumorigenic in animals. Although soot is considered to be a human carcinogen, soots from different combustion sources and fuels contain variable quantities of organic tars of somewhat different composition. This presents a serious problem when assessing risk since it is not possible to collect human cancer risk data for all the various possible exposures to combustion emissions. Furthermore it is impossible to collect human cancer data for exposures to emissions from new technologies which have not previously been in the environment. The use of chronic animal testing for each new combustion technology developed would be prohibitively expensive and time consuming. This problem has motivated us to develop and test a comparative potency risk assessment methodology which would utilize short-term mutagenesis and tumorigenesis data.
PUB Date Free Form Oct 85
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 601715902
Origin NTIS
Type CAT