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RECORD NUMBER: 285 OF 1145

OLS Field Name OLS Field Data
Main Title Comparative Histopathological Effects of Chemically Contaminated Sediment on Marine Organisms.
Author Gardner, G. R. ; Yevich, P. P. ;
CORP Author Environmental Research Lab., Narragansett, RI.
Publisher c1988
Year Published 1988
Report Number ERNL-806 ;EPA/600/J-88/464;
Stock Number PB90-147828
Additional Subjects Malignant neoplasms ; Marine biology ; Black Rock Harbor ; Connecticut ; Exposure ; Reprints ; Carcinogenicity tests ; Mutagenicity tests ; Water pollution effects(Animals) ; Toxic substances ; Dose-response relationships
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NTIS  PB90-147828 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 8p
Abstract Comparative pathological effects in three species of fish and six species of invertebrates were investigated using a chemically contaminated sediment from Black Rock Harbor (BRH), Connecticut, USA. Substances contained in BRH sediment are known to be genotoxic, carcinogenic, co-carcinogenic and tumor-promoting. Proliferative lesions were observed in winter flounder (Pseudopleuronectes americanus) external, oral and esophageal epithelial surfaces, renal vascular and nephroblastic elements, and the pancreatic islets. Islet lesions included cystic adenomas and a diffuse islet proliferative condition, nesidioblastosis. In addition, pathology was enhanced when winter flounder were fed mussels (Mytilus edulis) previously exposed to BRH sediment. Neoplastic lesions developed in kidney tubule epithelia, gills, some regions of the gastrointestinal tract, neural elements and heart of oysters (Crassostrea virginica) exposed to BRH sediment for 30 days in the laboratory. In addition, renal carcinomas in three oysters had metastasized to the visceral ganglion. (Copyright (c) 1988 Elsevier Applied Science Publishers, Ltd.)
Supplementary Notes Pub. in Marine Environmental Research, v24 p311-316 1988.
NTIS Title Notes Journal article.
Title Annotations Reprint: Comparative Histopathological Effects of Chemically Contaminated Sediment on Marine Organisms.
Category Codes 57Y; 57O; 47D; 68D
NTIS Prices PC A02/MF A01
Primary Description 600/05
Document Type NT
Cataloging Source NTIS/MT
Control Number 007531423
Origin NTIS
Type CAT