||Chemical and Radiation Leukemogenesis in Humans and Rodents and the Value of Rodent Models for Assessing Risks of Lymphohematopoietic Cancers.
Eastmond, D. A. ;
||Calilfornia Univ., Riverside. Environmental Toxicology Graduate Program.;Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
||NCEA-W-0275 ; EPA/600/R-97/090
Chemical warfare agents ;
Ionizing radiation ;
Genetic effects ;
Animal models ;
Toxic substances ;
Alkylating agents ;
Chromosomal aberrations ;
Genetic radiation effects ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||This report is intended to provide an up-to-date overview of the lymphoid and hematopietic diseases induced in humans and rodents following exposure to chemical agents. It includes a brief introduction to hematopoiesis and lymphopoiesis in humans and rodents, selected characteristics of known leukemia-inducing agents and their effects in mice and rats are compared and the value of rodents models. Six different classes of established leukemia-inducing agents were included: in ionizing radiation, alkylatingagents, epipodophyllotoxin-type topoisomerase inhibitors, dioxopiperazine-type topoisomerase inhibitors, benzene, and 1,3 butadiene. The current understanding of mechanisms underlying acute nonlymphocytic leukemia in humans and thymic lymphoma and myeloid leukemia in mice is presented. The relevance of mouse models for human leukemias and lymphomas is discussed. Furthermore, chronic animal bioassays using mouse models have been shown to be effective in identifying human leukemia-inducing agents.
||Sponsored by Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
||Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)321-8547; and email at email@example.com. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
||57F; 57O; 57Y
||PC A08/MF A02