||Aerosol Therapy Implications of Particle Deposition Patterns in Simulated Human Airways.
Martonen, T. B. ;
||Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;North Carolina Univ. at Chapel Hill. Dept. of Medicine.
Drug administration routes ;
Bronchial neoplasms ;
Respiratory system ;
Anatomical models ;
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||The efficacy of inhalation therapy may be improved by the selective deposition of aerosolized medicines, by explicitly targeting and delivering drugs to prescribed lung sites. Here, the deposition patterns of test aerosols, mapped in surrogate respiratory tracts consisting of replica laryngeal casts and fabricated tracheobronchial models, are analyzed. Particles were preferentially deposited at bifurcations, specifically at carinal ridges. Evidence from other investigations indicates that mucociliary clearance may be impeded at such sites in vivo. When these two effects are coupled, the findings suggest that epithelial cells and receptors at airway branching sites may receive concentrated doses of inhaled pharmacological agents. To focus the effects of airborne drugs the lung should, therefore, be considered as a serial network of Y-shaped bifurcation units. The findings have important implications to aerosol therapy protocols including: (1) the treatment of bronchogenic carcinomas because malignant tumors have a predilection for upper airway bifurcations; and (2) lung diseases related to the afferent nervous system since components of neural pathways frequent such locations.
||Pub. in Jnl. of Aerosol Medicine, v4 n1 p25-40 Feb 91. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Medicine.
|NTIS Title Notes
||Reprint: Aerosol Therapy Implications of Particle Deposition Patterns in Simulated Human Airways.
||PC A03/MF A01