Main Title |
Hepatic Neoplasms in the Mummichog 'Fundulus heteroclitus' from a Creosote-Contaminated Site. |
Author |
Vogelbein, W. K. ;
Fournie, J. W. ;
Van Veld, P. A. ;
Huggett, R. J. ;
|
CORP Author |
Environmental Research Lab., Gulf Breeze, FL. ;Virginia Inst. of Marine Science, Gloucester Point. ;Virginia State Water Control Board, Richmond. |
Publisher |
1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/385; |
Stock Number |
PB91-163980 |
Additional Subjects |
Water pollution ;
Toxicity ;
Creosote ;
Liver neoplasms ;
Water pollution effects(Animals) ;
Carcinogenicity tests ;
Polycyclic aromatic hydrocarbons ;
Sediments ;
Elizabeth River(Virginia) ;
Pathology ;
Reprints ;
Fundulus heteroclitus
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-163980 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
High prevalences of idiopathic hepatic lesions were found in mummichog, Fundulus heteroclitus from a site in the southern branch of the Elizabeth River, Virginia contaminated with polycyclic aromatic hydrocarbons (PAHs). Gross hepatic lesions occurred in 93% of the individuals from this site, whereas no hepatic lesions were detected in fish from two less contaminated sites. Lesions included foci of cellular alteration, hepatocellular adenoma, early and advanced hepatocellular carcinomas and cholangiocellular proliferative lesions. Advanced carcinomas exhibited several distinct cellular patterns and some livers contained multiple neoplasms occupying up to 80% of the hepatic parenchyma. These findings indicate a strong positive association between exposure to creosote-contaminated sediments and the high prevalence of hepatic neoplasms in a feral population of mummichog, and support the putative role of PAHs in fish hepatocarcinogenesis. Additionally, they suggest that the mummichog may be a useful indicator of exposure to carcinogens in aquatic environments. |
Supplementary Notes |
Pub. in Cancer Research, v50 p5978-5986, Sep 90. Also pub. as Virginia Inst. of Marine Science, Gloucester Point rept. no. CONTRIB-1603. Prepared in cooperation with Virginia Inst. of Marine Science, Gloucester Point, and Virginia State Water Control Board, Richmond. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Hepatic Neoplasms in the Mummichog 'Fundulus heteroclitus' from a Creosote-Contaminated Site. |
Category Codes |
68D; 57Y; 57E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/04 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
113027796 |
Origin |
NTIS |
Type |
CAT |