||Twenty-eight Day Dermal Toxicity Study of API 83-15 in the Rabbit (Final Draft Report) with Cover Letter dated 02/12/86.
||American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Environmental health ;
Public health ;
Animal experiments ;
Dermal toxicity ;
API 83-12 ;
Light alkylate naptha
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The test article, API 83-15, was applied to the shaved intact skin of New Zealand White rabbits three times a week for a total of 12 applications over a 28-day period. The test article was applied at dose levels of 200 (Group 2), 1000 (Group 3), and 2000 (Group 4) mg/kg to groups of five male and five female rabbits. In addition, five male and five female rabbits served as sham-treated negative controls. All animals were observed twice daily for toxic and pharmacologic signs; dermal irritation was scored daily (according to the Draize System (a)). Body weights were measured and recorded for each rabbit at the end of the quarantine period, at weekly intervals during the study, and prior to termination.
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