||Letter to USEPA regarding preliminary Information on Observations Made after 24 Months of a Lifetime Skin Painting Carcinogenicity Assay on Mice Treated with Xb-2793 (Sanitized).
||CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Chronic toxicity ;
Environmental fate ;
Production and process ;
Gene mutations ;
In vitro ;
CAS No 15336-81-9 ;
CAS No 25068-38-6 ;
CAS No 68140-30-7
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||A summary of preliminary results from a lifetime skin painting carcinogenicity assay on mice treated with XB-2793, a mixture containingabout 70% 2,4-imidazolinedione,5,5- dimethyl-1,3-bis (oxiranylmethyl)-C11H16O4 and 30% 2,4-imidazolidiendione, 5,5-dimethyl-, polymer with chloromethoxirane andmethyloxirane. At 24 treatment months, gross observations revealed skin tumors at the application site. In vitro mutagenicity screening assays of this product with Salmonella typhimurium showed evidence of mutagenicactivity in 3 of 4 test batches, both with and without metabolic activation, and no evidence of mutagenicity for the other batch. Furthertests with this latter batch gave positive results in the L5178Y mouse lymphoma assay and negative results with Saccharomyces cerevisiae, both with and without activation. S. typhimurium plate assays of a second product, XB-2826, a mixture containing predominantly XB2793, with some 4,4'-(1-methylethy lidene)bisphenol, showed evidence of mutagenesis both with and without metabolic activation, and assays with C. cerevisiae were negative for mutagenic activity. Further experimental details were not provided.
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||57Y; 57U; 68G; 99; 48G
||PC A24/MF A24