| Main Title |
Letter to USEPA regarding preliminary Information on Observations Made after 24 Months of a Lifetime Skin Painting Carcinogenicity Assay on Mice Treated with Xb-2793 (Sanitized). |
| CORP Author |
CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1980 |
| Report Number |
8EHQ-0180-0328S |
| Stock Number |
OTS0200617 |
| Additional Subjects |
Toxicology ;
Health effects ;
Chronic toxicity ;
Mammals ;
Mice ;
Dermal ;
Environmental fate ;
Production and process ;
Genotoxicity ;
Gene mutations ;
Bacteria ;
In vitro ;
CAS No 15336-81-9 ;
CAS No 25068-38-6 ;
CAS No 68140-30-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0200617 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
539p |
| Abstract |
A summary of preliminary results from a lifetime skin painting carcinogenicity assay on mice treated with XB-2793, a mixture containingabout 70% 2,4-imidazolinedione,5,5- dimethyl-1,3-bis (oxiranylmethyl)-C11H16O4 and 30% 2,4-imidazolidiendione, 5,5-dimethyl-, polymer with chloromethoxirane andmethyloxirane. At 24 treatment months, gross observations revealed skin tumors at the application site. In vitro mutagenicity screening assays of this product with Salmonella typhimurium showed evidence of mutagenicactivity in 3 of 4 test batches, both with and without metabolic activation, and no evidence of mutagenicity for the other batch. Furthertests with this latter batch gave positive results in the L5178Y mouse lymphoma assay and negative results with Saccharomyces cerevisiae, both with and without activation. S. typhimurium plate assays of a second product, XB-2826, a mixture containing predominantly XB2793, with some 4,4'-(1-methylethy lidene)bisphenol, showed evidence of mutagenesis both with and without metabolic activation, and assays with C. cerevisiae were negative for mutagenic activity. Further experimental details were not provided. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
Jan 1980 |
| Category Codes |
57Y; 57U; 68G; 99; 48G |
| NTIS Prices |
PC A24/MF A24 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500520 |
| Origin |
NTIS |
| Type |
CAT |
