||Letter from Gulf Oil Company to USEPA Regarding Information on the Mutation Assay and In Vitro Cell Transformation Testing Conducted at EG&G Mason Laboratories.
||Gulf Refining and Marketing Co., Houston, TX.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||9 Feb 1981
In vitro analysis ;
Laboratory tests ;
US EPA ;
Gulf Oil Company
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||This test involves the growth of mice cells in culture dishes in the presence of the material being tested (the experimental protocol used is a modification of that described by Clive, D. and Spector, J.F.S., Laboratory Procedure for Assessing Specific Locus Mutations at the TK Locus in Cultured L5178Y Mouse Lymphoma Cells. Mutation Research 31:17-29, (1975)). After the 'exposure' period, the cells are washed and placed in a growth medium which restricts the growth of 'normal' cells. Only mutant cells should grow in this medium. Control groups are used to detect the growth of any non-exposed cells in the medium.
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||PC A16/MF A03