| Main Title |
Salmonella/Mammalian-Microsome Preincubation Mutagenicity Assay using Arconol with Cover Letter dated 03/24/94. |
| CORP Author |
Arco Chemical Co., Newton Square, PA.; EG and G Mason Research Inst., Worcester, MA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
8EHQ-86940000260 |
| Stock Number |
OTS0572363 |
| Additional Subjects |
Toxicology ;
Health effects ;
Arconol ;
Toxicity ;
Genotoxicity ;
Gene mutations ;
Bacteria ;
In Vitro ;
CAS No 75-65-0 ;
Toxic substances ;
Laboratory animals
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0572363 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
40p |
| Abstract |
This study was run in both the presence and absence of metabolic activation. No mutagenic response was seen in four of the tester strains. However, in the fifth strain (TA-1535), a doubling of background mutation frequency was achieved, but only at the largest concentration tested (10 ul/plate). This response was not obtained in similar studies with high-purity TBA (99.9%). Moreover, this response is quite surprising, since the more sensitive tester strain for base-pair substitution (TA-100) showed no effect of G-TBA treatment whatsoever. This result is interpreted as a spurious one which either may not be repeatable or may have been due to a trace contaminant. The weak results seen in this study do not allow a conclusion that G-TBA is mutagenic in this assay system. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
Mar 1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010501220 |
| Origin |
NTIS |
| Type |
CAT |
