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OLS Field Name OLS Field Data
Main Title Assessment of the Propensity for Covalent Binding of Electrophiles to Biological Substrates.
Author Carlson, R. M. ;
CORP Author Minnesota Univ.-Duluth.;Environmental Research Lab.-Duluth, MN.
Publisher c1990
Year Published 1990
Report Number EPA-R813144-02 ;EPA-R813943; EPA/600/J-90/251;
Stock Number PB91-144949
Additional Subjects Deoxyribonucleic acids ; Electrophilic reactions ; Chemical bonds ; Carbonium ions ; Molecular structure ; Molecular biology ; Reprints ; Hard and soft acids
Library Call Number Additional Info Location Last
NTIS  PB91-144949 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/13/1991
Collation 8p
Abstract Electrophilic character is associated with the ability of external agents to interact with centers of electron density in biological macromolecules and to cause the interruption or alternation of normal activity. With the observation of site specificity in mutagenic events, Pearson's hard/soft acid-based (HSAB) theory is presented as a useful concept in correlating chemical observations in the absence of detailed direct knowledge of the process. Methods for the evaluation of carbon electrophiles (e.g., carbocation character) as reactants are reviewed as potential physical parameters that could be applied in developing quantitative structure-activity relationships.
Supplementary Notes Pub. in Environmental Health Perspectives, v87 p227-232 1990. Sponsored by Environmental Research Lab.-Duluth, MN.
NTIS Title Notes Journal article.
Title Annotations Reprint: Assessment of the Propensity for Covalent Binding of Electrophiles to Biological Substrates.
Category Codes 99F; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/03
Document Type NT
Cataloging Source NTIS/MT
Control Number 109129933
Origin NTIS
Type CAT