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OLS Field Name OLS Field Data
Main Title Histone Recognition [electronic resource] /
Type EBOOK
Other Authors
Author Title of a Work
Zhou, Ming-Ming.
Publisher Springer International Publishing : Imprint: Springer,
Year Published 2015
Call Number QP110.G45
ISBN 9783319181028
Subjects Medicine. ; Gene expression. ; Medical genetics. ; RNA-ligand interactions. ; Post-translational modification of proteins.
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-3-319-18102-8
Collation VIII, 282 p. 69 illus., 51 illus. in color. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes The Bromodomain as the Acetyl-Lysine Binding Domain in Gene Transcription -- PHD Fingers as Histone Readers -- Methyl-Lysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains -- Histone Recognition by WD40 Proteins -- Methyl-Lys Recognition by Ankyrin Repeat Proteins -- Methyl-Arginine Recognition by Tudor Domains -- Histone Recognition by Tandem Modules and Modulation by Multiple PTMs -- Genome-Wide Profiling of Molecular Recognition of Histone PTMs -- BET Bromodomain Inhibition as a Therapeutic Approach in Hematological Malignancies -- Anti-Inflammatory Effects of BET Protein Inhibition Through Modulation of Gene Transcription -- Activating Latent HIV by Inhibiting Bromodomain Proteins -- Small Molecule Modulation of Methyl-Lysine Mediated Interactions. This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.
Place Published Cham
Corporate Au Added Ent SpringerLink (Online service)
Host Item Entry Springer eBooks
PUB Date Free Form 2015
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20150530021715
Language eng
Origin SPRINGER
Type EBOOK
OCLC Rec Leader 03171nam a22004815i 45