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RECORD NUMBER: 51 OF 65

OLS Field Name OLS Field Data
Main Title Plasma Proteins and Colloid Osmotic Pressure of Blood of Rat Fetuses Prenatally Exposed to Mirex.
Author Grabowski, Casimer T. ;
CORP Author Miami Univ., Coral Gables, FL. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-R-805301; EPA-600/J-81-211;
Stock Number PB82-238460
Additional Subjects Pesticides ; Toxicology ; Rats ; Laboratory animals ; Insecticides ; Edema ; Physiological effects ; Chlorine aliphatic compounds ; Reprints ; Fetuses ; Mirex ; Methanocyclobuta(cd)pentalenes
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NTIS  PB82-238460 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Abstract A significant effect of prenatal exposure to the pesticide Mirex is a fetal edema, which is responsible for many of the toxic effects of this agent. Pregnant rats were given 6 mg/kg mirex on d 8 and a half-15 and a half, a moderate dose that does not cause maternal mortality. The blood of 18 and a half- and 20 and a half-d rat fetuses was tested to determine a possible cause of the edema. There were no significant differences between fetal and maternal plasma or between control and treated fetal plasma with respect to sodium and potassium concentrations or total osmolality. The protein concentration of plasma of treated fetuses was lower than that of controls. This effect was proportional to the degree of edema. The concentration in 20 and a half-d controls was 25.2 mg/ml, that in mildly swollen treated fetuses 18.l mg/ml, and that in severely swollen ones 13.5 mg/ml. Polyacrylamide gel electrophoresis showed quantitative and qualitative changes in plasma of affected fetuses. The colloid osmotic pressure was also reduced from 8.0 mm in controls and unaffected treated fetusesto 4.8 mm in swollen fetuses. Since lowered plasma protein and colloid osmotic pressure cause tissue edema in adults, they are the probable cause of mirex-induced fetal edema.
Supplementary Notes Pub. in Jnl. of Toxicology and Environmental Health 7, p705-714 1981.
NTIS Title Notes Journal article.
Title Annotations Reprint: Plasma Proteins and Colloid Osmotic Pressure of Blood of Rat Fetuses Prenatally Exposed to Mirex.
PUB Date Free Form 1981
Category Codes 6T; 6F; 57Y; 68E
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323820415
Origin NTIS
Type CAT