Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 46 OF 65

OLS Field Name OLS Field Data
Main Title Oral Toxicity of Mirex in Adult and Suckling Rats, with Notes on the Ultrastructure of Liver Changes.
Author Gaines, Thomas B. ; Kimbrough., Renate D. ;
CORP Author Food and Drug Administration, Chamblee, Ga.
Year Published 1970
Stock Number PB-280 003
Additional Subjects Pesticides ; Insecticides ; Toxicology ; Chlorine aliphatic compounds ; Bioassay ; Rats ; Laboratory animals ; Toxicity ; Reproduction(Biology) ; Ingestion(Biology) ; Dosage ; Lethal dosage ; Females ; Males ; Liver ; Pathology ; Histology ; Reprints ; Mirex ; Fetuses ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB-280 003 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract The oral toxicity of mirex and its effect on reproduction was studied in rats. The one-dose oral lethal dose for 50% survival of the group (LD50) in females was 365 mg/kg/day; the 90-dose oral LD50 was 6 mg/kg/day. The chronicity factor was 60.8. Females fed 25 ppm mirex had fewer offspring born alive, significantly fewer offspring survived to weaning, and many pups developed cataracts. Females fed 5 ppm produced normal litters. Offspring born to mothers fed 25 ppm mirex and nursed by nontreated foster mothers had a low incidence of cataracts and a normal survival rate to weaning. Gas chromatographic analysis of milk and fetuses showed excretion of mirex in the milk and passage through the placental barrier. Livers of male and female rats fed 25 ppm mirex weighed significantly more than controls. Proliferation of smooth endoplasmic reticulum and osmiophilic dense bodies were observed in these livers with the electron microscope.
Supplementary Notes Pub. in Arch Environ Health, v21 p7-14, Jul 70.
Availability Notes Included in the report, Journal Articles on Toxicology. Group 11, PB-280 001.
Title Annotations Reprint: Oral Toxicity of Mirex in Adult and Suckling Rats, with Notes on the Ultrastructure of Liver Changes,
PUB Date Free Form 16 Jan 70
Category Codes 6T; 57Y; 68G; 68E
NTIS Prices (Order as PB-280 001, MF A01)
Primary Description 500/01
Document Type NT
Cataloging Source NTIS/MT
Control Number 323739353
Origin NTIS
Type CAT