||Microinjection of Dynorphin into the Hippocampus Impairs Spatial Learning in Rats.
McDaniel, K. L. ;
Mundy, W. R. ;
Tilson., H. A. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Lab. of Molecular and Integrative Neuroscience.
Dose-response relationships ;
Endogenous substances receptors
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The effect of hippocampal dynorphin administration on learning and memory was examined in spatial and nonspatial tasks. Bilateral infusion of dynorphin A(1-8)(DYN; 10 or 20 micrograms in one microliter) into the dorsal hippocampus resulted in dose-related impairment of spatial working memory in a radial maze win-stay task. Subsequent experiments found that acquisition of a reference memory task in the water maze was impaired by DYN injections (20 micrograms/microliter) in the dorsal hippocampus, but not in the ventral hippocampus, and that this impairment could be blocked by naloxone. In a nonspatial task, posttraining DYN injections in the dorsal hippocampus had no effect on retention of step-through passive avoidance. These results suggest that dynorphin specifically interferes with spatial learning and memory, and that this effect is mediated by opioid receptors in the dorsal hippocampus.
||Pub. in Pharmacology Biochemistry and Behavior, v35 p429-435 1990. Prepared in cooperation with North Carolina State Univ. at Raleigh, and National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Lab. of Molecular and Integrative Neuroscience.
|NTIS Title Notes
||Reprint: Microinjection of Dynorphin into the Hippocampus Impairs Spatial Learning in Rats.
||PC A02/MF A01