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RECORD NUMBER: 462 OF 1229

OLS Field Name OLS Field Data
Main Title Initial Submission: Isophorone: Significance of the Toxicology and Carcinogenicity in Fischer 344 Rats and B6C3F1 Mice with Cover Letter dated 09/24/1992.
CORP Author Papanicolaou Cancer Research Inst., Miami, FL.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0992-11057
Stock Number OTS0571092
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Isophorone ; Chronic toxicity ; Carcinogenicity ; Mammals ; Rats ; Oral ; Gavage ; Mice ; CAS No 78-59-1
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NTIS  OTS0571092 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/27/2010
Collation 29p
Abstract Isophorone when administered in corn oil and by stomach tube at dosage levels of 250 or 500 mg/kg was associated with an increased incidence of renal and preputial tumors in male rats, an increased incidence of liver tumors in male mice, but did not exhibit carcinogenic potential in either female rats or mice. Thus, under the conditions of this bioassay, isophorone appeared to exhibit weak carcinogenic activity.
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PUB Date Free Form 24 Sep 1992
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A03/MF A03
Document Type NT
Cataloging Source NTIS/MT
Control Number 018800820
Origin NTIS
Type CAT