||Initial Submission: Isophorone: Significance of the Toxicology and Carcinogenicity in Fischer 344 Rats and B6C3F1 Mice with Cover Letter dated 09/24/1992.
||Papanicolaou Cancer Research Inst., Miami, FL.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Toxic substances ;
Chronic toxicity ;
CAS No 78-59-1
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Isophorone when administered in corn oil and by stomach tube at dosage levels of 250 or 500 mg/kg was associated with an increased incidence of renal and preputial tumors in male rats, an increased incidence of liver tumors in male mice, but did not exhibit carcinogenic potential in either female rats or mice. Thus, under the conditions of this bioassay, isophorone appeared to exhibit weak carcinogenic activity.
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|PUB Date Free Form
||24 Sep 1992
||57Y; 57U; 68G; 99; 44G
||PC A03/MF A03