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RECORD NUMBER: 282 OF 1236

OLS Field Name OLS Field Data
Main Title Enhancement of Natural Killer Cell Activity and Interferon Production by Manganese in Young Mice.
Author Smialowicz, R. J. ; Riddle, M. M. ; Rogers, R. R. ; Luebke, R. W. ; Burleson, G. R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/J-88/019;
Stock Number PB88-219738
Additional Subjects Mice ; Laboratory animals ; Manganese ; Immunity ; Reprints ; Natural killer cell ; Activity(Biology) ; Manganese chloride ; Immunotoxicity
Holdings
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NTIS  PB88-219738 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/29/1988
Collation 17p
Abstract The effect that MnCl2 has on murine splenic natural killer (NK) cell activity was investigated in infant (10 days old), pre-weanling (18 days old) and weanling (24 days old) C57BL/6J mice. Both MnCl2 and Poly I:C caused elevations in serum interferon levels. Time-course studies revealed that interferon levels returned to normal within 48 hours following injection with either MnCl2 or Poly I:C; however enhanced NK activity persisted for up to 48 hours in Poly I:C-injected mice and 72 hours in MnCl2-injected mice. These results indicate that despite low levels of NK activity in pre-weanling mice, MnCl2 is capable of enhancing this activity by 8-9 fold. Furthermore, Mn-enhanced NK activity in these young mice appears to be mediated by the production of interferon alpha, beta.
Supplementary Notes Pub. in Immunopharmacology and Immunotoxicology, v10 n1 p93-107 1988. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Enhancement of Natural Killer Cell Activity and Interferon Production by Manganese in Young Mice.
PUB Date Free Form c1988
Category Codes 57J; 57Y
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 826014798
Origin NTIS
Type CAT