Main Title |
Developmental Toxicity of Bromoxynil in Mice and Rats. |
Author |
Rogers, J. M. ;
Francis, B. M. ;
Barbee, B. D. ;
Chernoff, N. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Illinois Univ. at Urbana-Champaign. Inst. for Environmental Studies. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/264; |
Stock Number |
PB92-113265 |
Additional Subjects |
Toxicity ;
Teratogenic compounds ;
Herbicides ;
Rats ;
Mice ;
Dose-response relationships ;
Esters ;
Body weight ;
Organ weight ;
Mortality ;
Liver ;
Spleen ;
Thymus gland ;
Adrenal glands ;
Reprints ;
Supernumerary ribs ;
Bromoxynil
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-113265 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The developmental toxicity of the wide-spectrum herbicide bromoxynil (bromoxynil phenol; 3,5-dibromo-4-hydroxyphenyl cyanide) was evaluated in Sprague-Dawley rats and Swiss-Webster mice, and the developmental toxicity of its octanoate ester (2,6-dibromo-4-cyanophenyl octanoate) was evaluated in Sprague-Dawley rats. Animals were treated from Day 6 to Day 15 of gestation (presence of sperm or semen plug = 0 of gestation). The doses administered were as follows: bromoxynil phenol in the mouse, 342, 114, and 38 micromoles/kg/day; bromoxynil phenol and bromoxynil octanoate in the rat, 54, 18, and 6 micromoles/kg/day. Some animals were killed on selected days during treatment for measurement of organ weights sensitive to stress. In mice treated with bromoxynil phenol, maternal mortality was noted at 114 and 342 micromoles/kg/day, but surviving females gained weight normally. Liver to body weight ratios increased with increasing dose, but no consistent effect was seen on adrenal, thymus, or spleen weights. Fetuses of mice treated with the highest dose of bromoxynil phenol were of lower weight and had a higher incidence of supernumerary ribs than controls. In rats, bromoxynil phenol and its octanoate ester at the highest doses used caused no mortality but resulted in only transient decreases in maternal weight gain and significantly increased the liver to body weight ratio, but did not significantly alter adrenal, thymus, or spleen weight in the dams. (Copyright (c) 1991 by the Society of Toxicology.) |
Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v17 n3 p442-447 Oct 91. Prepared in cooperation with Illinois Univ. at Urbana-Champaign. Inst. for Environmental Studies. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Developmental Toxicity of Bromoxynil in Mice and Rats. |
Category Codes |
57Y; 57S; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
135322283 |
Origin |
NTIS |
Type |
CAT |