||Dehp Metabolism Studies Protocol Ii Species Differences in the Metabolism of a Single Oral Dose of Dehp.
||Bio-Dynamics Research and Development Corp., Eugene, OR.; Hooker Chemical Corp., Burlington, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Benzylbutyl Phthalate ;
Pharmaco Kinetics ;
Toxic substances ;
Laboratory animals ;
CAS No 117-81-7
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Pharmacokinetics of di(2-ethylhexyl)phthalate (DEHP) were evaluated in 3 male Cynomolgus monkeys, 5 male Fischer-344 rats, and 5 groups of male B6C3F1 mice (5/group) fed a single nominal dose of 100 mg 14-C-DEHP/kg bw by gavage. All species excreted approximately 30-40% of the dose via the urinary route, primarily during the first 12 hours for rats and mice, and during the first 24 hours for monkeys. Only minimal excretion (ca. 5% or less of the dose) occurred after 24 hours in all species. All species excreted approximately 50% of the dose via the fecal route, primarily during the first 24 hours for rats and mice, and during the first 48 hours for monkeys. DEHP equivalents were detectable in some tissues in all species. The mean concentrations detected, with the exception of monkey liver and rat intestinal contents, were less than 1 ug/g. The highest concentrations were detected in the liver, intestinal contents, and fat for monkeys, rats, and mice, respectively. Total recoveries of the 14C-DEHP radioactivity administered were 79, 87, and 90% for monkeys, rats, and mice, respectively.
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||57Y; 57U; 68G; 99; 44G
||PC A07/MF A07