| Main Title |
NTP Technical Report on the Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CAS No. 7220-79-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
| CORP Author |
National Toxicology Program, Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic; Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Globals Centers for Health and Environmental Sciences. |
| Year Published |
2008 |
| Report Number |
8EHQ-07-16715 |
| Stock Number |
OTS0600505 |
| Additional Subjects |
Health effects ;
Methylene blue trihydrate ;
Toxicity ;
Rats ;
Mice ;
Gavage studies ;
CAS No 7220-79-3 ;
Toxicology ;
1-1-2-2-tetrafluoroethanesulfonic acid anhydride ;
Oral toxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0600505 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1p |
| Abstract |
Methylene blue trihydrate has a variety of biomedical and biologically therapeutic applications. Methylene blue trihydrate was nominated by the National Cancer Institute (NCI) for carcinogenicity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of methylene blue trihydrate, as well as the inadequate animal data on this compound. Male and female F344/N rats and B6C3F1 mice were administered methylene blue trihydrate in 0.5% aqueous methylcellulose by gavage for 1 month, 3 months, or 2 years. Genetic toxicology studies were conducted using Salmonella typhimurium,Escherichia coli, cultured Chinese hamster ovary cells, mouse bone marrow cells, and mouse peripheral blood erythrocytes. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
| PUB Date Free Form |
May 2008 |
| Category Codes |
57Y | Toxicology; 57U | Public Health & Industrial Medicine; 68G | Environmental Health & Safety; 44G | Environmental & Occupational Factors |
| NTIS Prices |
PC A01 |
| Document Type |
NT |
| Medium |
CA | CA; DL | DL; MF | XM; PC | PO |
| Cataloging Source |
NTIS/MT |
| Control Number |
120502210 |
| Origin |
NTIS |
| Type |
CAT |
