Main Title |
Letter to Usepa Regarding Enclosed Mouse Sensory Irritation - Method Verification Study on 2-propenal with Attachments (Sanitized). |
CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1991 |
Report Number |
86-920000386S |
Stock Number |
OTS0533724 |
Additional Subjects |
Toxicology ;
Health effects ;
Confidential ;
2-propenal (107-02-8) ;
Acute Toxicity ;
Mammals ;
Mice ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 107-02-8
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0533724 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
20p |
Abstract |
Acrolein (CAS No. 107-02-8) with several other chemicals was evaluated for sensory (upper airway) irritation in a modified Alarie Mouse Sensory Irritation Test. Four each male Swiss Albino CD-1 mice were administered dynamic head only exposures to vapor concentrations of 0.0 to 8.7 ppm in air over 10 minutes to characterize type response as either immediate and persisting, immediate with accommodation (ameliorated with time), or immediate and progressive during exposures. Concentrations below 2 ppm produced a linear response (breaths/minute/animal) curve, while maximal responses (decreased respiration rate) occurred after 10 minutes' exposure, thus indicating a progressive response to exposure without physiological accommodation or compensation; an RD50 (linear regression determination of that concentration causing 50% reduction of respiratory rate) was 1.27 ppm (R=0.89; 95% CL 1.07-1.52 ppm). Response data were not provided. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
1991 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028803180 |
Origin |
NTIS |
Type |
CAT |