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RECORD NUMBER: 22 OF 71

OLS Field Name OLS Field Data
Main Title In vitro Study of Embryotoxic and Dysmorphogenic Effects of Mercuric Chloride and Methylmercury Chloride in the Rat.
Author Kitchin, K. T. ; Ebron, M. T. ; Svendsgaard, D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-600/J-84-015;
Stock Number PB84-197581
Additional Subjects Toxicology ; Rats ; Laboratory animals ; In vitro analysis ; Reprints ; Mercuric chloride ; Methylmercury chloride ; Dysmorphogeny ; Embryotoxicity
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NTIS  PB84-197581 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract Rat-embryo explants removed on day 10.5 of gestation were cultured for 48 hr in various concentrations of HgCl2 CH3HgCl or glutathione. Dose-related dysmorhogenesis and growth retardation occurred with increasing concentrations of HgCl2 (1-10 micro M). Increasing concentrations of CH3HgCl (3-100 micro M) produced a similar pattern of embryonic effects. The rat-serum incubation medium had no detectable level of reduced glutathione (0.02 mM) and only 0.12 mM total sulphydryl groups. Reduced glutathione (60-300 micro M) added to the incubation medium was relatively non-toxic. The addition of exogenous glutathione to culture medium containing HgCl2 partially antagonized the embryonic growth retardation and prevented most of the embryolethality observed in cultures to which only HgCl2 had been added.
Supplementary Notes Pub. in Fundamentals in Chemical Toxicology, v22 n1 p31-37 1944.
NTIS Title Notes Journal article.
Title Annotations Reprint: In vitro Study of Embryotoxic and Dysmorphogenic Effects of Mercuric Chloride and Methylmercury Chloride in the Rat.
PUB Date Free Form 1984
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 423020812
Origin NTIS
Type CAT