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OLS Field Name OLS Field Data
Main Title Flow Cytometric Analysis of the Mechanism of Methylmercury Cytotoxicity.
Author Zucker, R. M. ; Elstein, K. H. ; Easterling, R. E. ; Massaro, E. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;NSI Technology Services Corp., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/353;
Stock Number PB91-163675
Additional Subjects Methylmercury compounds ; Toxicity ; Fluorescence spectrometry ; Cell survival ; Flow cytometry ; Dose-response relationships ; Cell membrane ; Erythro leukemia ; Culture tumor cells ; Cell cycle ; Chromosomes ; Mitosis ; Computerized simulation ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-163675 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/13/1991
Collation 13p
Abstract The target and degree of methylmercury cytotoxicity are dose-dependent. Following 6 h exposure to 2.5 - 7.5 microMolar, methylmercury (MeHg) progressively inhibits DNA synthesis and induces chromosomal damage in murine erythroleukemic cells. However, following exposure to 10 - 50 microMolar MeHg, the plasma membrane/cytoplasm complex is grossly perturbed, cell cycle progression is blocked, and chromosomes appear in ring formations. These findings, together with those previously observed following organotin exposure, also suggest that severe and nonspecific toxicity may be a common endpoint of exposure to high levels of organometals.
Supplementary Notes Pub. in American Jnl. of Pathology, v137 n5 p1187-1198 Nov 90. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Flow Cytometric Analysis of the Mechanism of Methylmercury Cytotoxicity.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 113027493
Origin NTIS
Type CAT