| Main Title |
Characterization of Data Uncertainty and Variability in IRIS Assessments: Pre-Pilot vs Pilot/Post-Pilot. |
| CORP Author |
Versar, Inc., Springfield, VA.; Environmental Protection Agency, Washington, DC. Office of Research and Development. |
| Year Published |
2008 |
| Report Number |
CN-68-C-99-238-TO-2 |
| Stock Number |
PB2012-100927 |
| Additional Subjects |
Human health ;
Toxicology ;
Risk assessment ;
Data bases ;
Health hazards ;
Dose-response relationships ;
Chemical composition ;
Sampling ;
Methodology ;
Information systems ;
Uncertainty ;
Variability ;
Documentation ;
Implementation ;
Integrated Risk Information System(IRIS)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB2012-100927 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
260p |
| Abstract |
This report presents the results of a scientific review of uncertainty and variability analysis and documentation in health assessments contained in the Integrated Risk Information System (IRIS). The review was conducted by six individuals with expertise in various areas of toxicology, human health risk assessment, and related fields. The objective was to perform an in-depth study of uncertainty and variability documentation in IRIS assessments, based on sixteen chemicals randomly selected from the 537 assessments currently in the IRIS database. Specifically, the review addressed uncertainty documentation in sixteen assessments that spanning the years 1988 to 2000. The first group of eight were selected from the assessments generated by EPA during the time period 1987 through 1994, also referred to as 'pre-Pilot' assessments. The second group of eight was selected from assessments released from 1995 to present, also referred to as 'Pilot/post-Pilot assessments.' Each IRIS assessment (the summary sheets and the Toxicological Review) was reviewed to determine how uncertainties in the data bases, modeling extrapolation, and other factors were considered in the development of toxicity values. Comparisons between the pre-Pilot and Pilot/post-Pilot groups were made as part of this review. |
| Supplementary Notes |
Sponsored by Environmental Protection Agency, Washington, DC. Office of Research and Development. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
| PUB Date Free Form |
28 Jul 2008 |
| Category Codes |
68G; 57Y; 57U |
| NTIS Prices |
PC A13/MF A13 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
102300330 |
| Origin |
NTIS |
| Type |
CAT |
