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RECORD NUMBER: 178 OF 1363

OLS Field Name OLS Field Data
Main Title Characterization of Data Uncertainty and Variability in IRIS Assessments: Pre-Pilot vs Pilot/Post-Pilot.
CORP Author Versar, Inc., Springfield, VA.; Environmental Protection Agency, Washington, DC. Office of Research and Development.
Year Published 2008
Report Number CN-68-C-99-238-TO-2
Stock Number PB2012-100927
Additional Subjects Human health ; Toxicology ; Risk assessment ; Data bases ; Health hazards ; Dose-response relationships ; Chemical composition ; Sampling ; Methodology ; Information systems ; Uncertainty ; Variability ; Documentation ; Implementation ; Integrated Risk Information System(IRIS)
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NTIS  PB2012-100927 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/29/2012
Collation 260p
Abstract This report presents the results of a scientific review of uncertainty and variability analysis and documentation in health assessments contained in the Integrated Risk Information System (IRIS). The review was conducted by six individuals with expertise in various areas of toxicology, human health risk assessment, and related fields. The objective was to perform an in-depth study of uncertainty and variability documentation in IRIS assessments, based on sixteen chemicals randomly selected from the 537 assessments currently in the IRIS database. Specifically, the review addressed uncertainty documentation in sixteen assessments that spanning the years 1988 to 2000. The first group of eight were selected from the assessments generated by EPA during the time period 1987 through 1994, also referred to as 'pre-Pilot' assessments. The second group of eight was selected from assessments released from 1995 to present, also referred to as 'Pilot/post-Pilot assessments.' Each IRIS assessment (the summary sheets and the Toxicological Review) was reviewed to determine how uncertainties in the data bases, modeling extrapolation, and other factors were considered in the development of toxicity values. Comparisons between the pre-Pilot and Pilot/post-Pilot groups were made as part of this review.
Supplementary Notes Sponsored by Environmental Protection Agency, Washington, DC. Office of Research and Development.
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PUB Date Free Form 28 Jul 2008
Category Codes 68G; 57Y; 57U
NTIS Prices PC A13/MF A13
Document Type NT
Cataloging Source NTIS/MT
Control Number 102300330
Origin NTIS
Type CAT